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Michael Frankel

Michael R. Frankel, MD

Chief of Neurology, Director of Marcus Stroke & Neuroscience Center

Since 1992, Dr. Michael Frankel has served as Chief of Neurology and Director of the Marcus Stroke and Neuroscience Center at Grady Memorial Hospital. He is also Professor of Neurology and Division Director of Vascular Neurology at Emory University School of Medicine.
In 1992, under his leadership, Grady Memorial Hospital became the first hospital in the Southeast to have a round-the-clock acute stroke team focusing on enrolling patients into the landmark NIH tPA Stroke Trial and leading to FDA approval in 1996. Since 2001, he has worked with numerous hospitals across GA to help them become “stroke ready” via the CDC’s Georgia Acute Stroke Coverdell Registry, which he initiated for Georgia in 2001 and currently serves as the Lead Neurologist for the state-based registry.
In 2010, Dr. Frankel and his team opened the Marcus Stroke & Neuroscience Center, a cutting-edge Comprehensive Stroke Center and the region’s premier referral site for patients with acute stroke. His team has pioneered new treatments and led the recently completed clinical trial called “DAWN”, published in the New England Journal of Medicine on November 11, 2017, providing definitive proof that thrombectomy (endovascular removal of blood clots inside cerebral arteries) dramatically improves outcomes for patients with acute stroke who arrive at the hospital between 6 and 24 hours from last known well and have favorable advanced brain imaging. This landmark trial is a paradigm shift for stroke care, ushering in a new era of defining a “tissue window” rather than just a “time window” for treatment.
Since 2013, Dr. Frankel has directed the NIH funded Georgia StrokeNet, one of 25 regional coordinating centers in the US focusing on enhancing recruitment into clinical trials of stroke prevention, intervention and recovery.
Dr. Frankel is extremely proud of the academic and clinical missions at Grady. His neuroscience team of clinicians, educators, and researchers focus on excellence in patient care, discovering new treatments, and training the next generation of healthcare providers.

Specialties

  • Neurology
  • Vascular Neurology

Board Certifications

  • ABMS Psychiatry/Neurology

Affiliations

  • Emory

Education & Training

  • Medical School: University of Louisville School of Medicine
  • Internship: Emory University School of Medicine
  • Residency: Emory University School of Medicine

Honors & Awards

1996 Neurology Faculty Teaching Award, presented by Emory Neurology residents.

1999 Best Neurology Faculty Teaching Award, presented by the Emory University Medical School graduating class of 1999.

1999 Special Recognition Award for Excellence in Teaching, presented by Emory Neurology residents.

2002 Neurology Faculty Teaching Award, presented by Emory Neurology residents

2007 Neurology Faculty Teaching Award, presented by Emory neurology residents

2008 Elected to Alpha Omega Alpha (AOA) by Emory Medical Students

2012 Health Care Hero Finalist – Atlanta Business Chronicle

2015 “Pioneering Neurologist of the Year Award” – presented by the Society of Vascular & Interventional Neurology (SVIN) at the annual international meeting.

2016 “Visionary Award” – presented by the Grady Health System at the Annual White Coat Gala

2017 Marcus Stroke Network established via generous gift from the Marcus Foundation, establishing a new and innovative telemedicine system for acute stroke, including the state's first mobile stroke ambulance

Publications

Krendel DA, Ditter SM, Frankel MR, Ross WK. Biopsy-proven cerebral vasculitis associated with cocaine abuse. Neurology 1990;40:1092-1094.

The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue Plasminogen Activator for Acute Ischemic Stroke, N Engl J Med 1995;333:1581-7.

Qureshi A, Safdar K, Weil J, Barch C, Bliwise D, Colohan A, Mackay B, Frankel MR. Predictors of Early Deterioration and Mortality in African-Americans after Intracerebral Hemorrhage. Stroke, Vol 26, No 10, October 1995, 1764-1767.

Qureshi A, Frankel MR. Loss of Autoregulation in Patients with Intracerebral Hemorrhage, J. Stroke Cerebrovasc Dis, Vol 5, No.3, 1995 163-165.

Qureshi A, Frankel MR, Ottenlips J, Stern B. Cerebral Hemodynamics in Eclampsia and Pre-eclampsia. Arch Neurol 1996; 53:1226-1231.

Lyden P, Grotta J, Levine S, Marler J, Frankel MR, Brott T. Intravenous Thrombolysis for Acute Stroke. Neurology 1997; 49:14-29.

Qureshi A, Janssen R, Karon J, Weissman JP, Akbar S, Safdar K, Frankel MR. Human Immunodeficiency Virus Infection and Stroke in Young Patients. Arch Neurol. 1997;54:1150-53.

Qureshi A, Muhammed A, Janssen R, Frankel MR. Intracerebral Hemorrhage in Blacks: Risk Factors Subtypes and Outcome. Stroke 1997; 28:961-64.

The NINDS rt-PA Stroke Study Group. Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke. Stroke 1997;28:2109-2118.

The NINDS rt-PA Stroke Study Group. Generalized efficacy of tPA for acute stroke: Subgroup analysis of the NINDS t-PA Stroke Trial. Stroke 1997; 28:2119-2125.

The NINDS rt-PA Stroke Study Group. A systems approach to immedicate evaluation and management of hyperacute stroke. Experience at 8 centers and implications for community practice and patient care. Stroke. 1997;28:1530-1540.

Qureshi A, Akbar MS, Czander E, Safdar K, Jannsen RS, Frankel MR. Crack Cocaine Use and Stroke in Young Patients. Neurology 1997; 48:341-45.

Fagan SC, Morgenstern LB, Petita A, Ward R, Tilley B, Marler J, Broderick J, Levine SR, Kwiatkowski T, Frankel MR, Walker MD and the NINDS rt-PA Stroke Trial Investigators. The cost effectiveness of t-PA for acute ischemic stroke. Neurology 1998;883-890.

Qureshi A, Safdar K, Patel M, Jannen RS, Frankel MR. Stroke in Young Black Patients, Risk Factors, Subtypes and Prognosis, Stroke, Vol 26, No. 11, November 1995, 1995-1998.

Brott T, Kothari R, Fagan S, Frankel MR, et al. Hypertension and its Treatment in the NINDS t-PA Stroke Study. Stroke, 1998; 29:1504-1509.

Qureshi A, Isa A, Cinnamon J, Fountain J, Ottenlips JR, Braimah J, Frankel MR. Magnetic resonance angiography in patients with brain infarction. Journal of Neuroimaging, 1998;8:65-70.

Lewandowski CA, Frankel MR, Tomsick TA, et al. Combined intravenous and intra-arterial rt-PA versus intra-arterial therapy of acute ischemic stroke: The Emergency Management of Stroke (EMS) Bridging Trial. Stroke. 1999;30:2598-2605.

Qureshi A, Frankel MR, et al. Rate of 24-hour Blood Pressure Decline and Mortality after spontaneous intracerebral hemorrhage: A retrospective analysis with a random effects regression model. Intracerebral Hemorrhage and Mortality. Crit Care Med, 1999; Vol 27, No 3, 480-485.

Kwiatkowski TG, Libman R, Frankel MR, Tilley B, Morgenstern LB, Lu M, Broderick J, Marler J, Brott T, and the NINDS t-PA Stroke Study Group. The NINDS rt-PA stroke study: The effects of t-PA for acute ischemic stroke at one year. N Engl J Med, 1999;340:1781-7.

Grotta JC, Chiu D, Liu M, Patel S, Levine SR, Tilley BC, Brott TG, Haley EC, Lyden PD, Kothari R, Frankel MR, et al. Agreement and Variability in the Interpretation of Early CT Changes in Stroke Patients Qualifying for Intravenous rtPA Therapy. Stroke, 1999; 30:1528-1533.

Qureshi A, Mohammad Y, Yahia AM, Luft AR, Sharma M, Tamargo RJ, Frankel MR. Ischemic events associated with unruptured intracranial aneurysms: multicenter clinical study and review of the literature. Neurosurgery 2000; 46(2):282-9.

Frankel MR, Morgenstern LB, Kwiatkowski T, Lu M, Tilley BC, Broderick JP, Libman R, Levine SR, Brott T. Predicting prognosis after stroke, A placebo group analysis from the National Institute of Neurological Disorders and Stroke rt-PA Stroke Trial. Neurology 2000;55:952-959.

Broderick JP, Lu M, Kothari R, Levine SR, Lyden PD, Haley EC, Brott TG, Grotta J, Tilley BC, Marler JR, Frankel M, and the NINDS rtPA Stroke Study Group. Finding the Most Powerful Measures of the Effectiveness of Tissue Plasminogen Activator in the NINDS tPA Stroke Trial. Stroke 2000;31:2335-2341.

Marler JR, Tilley BC, Lu M, Brott TG, Lyden PC, Grotta JC, Broderick JP, Levine SR, Frankel MR, Horowitz SH, Haley EC, Lewandowski CA, Kwiatkowski TP for the NINDS rt-PA Stroke Study Group. Early stroke treatment associated with better outcome. The NINDS rt-PA Stroke Study. Neurology 2000;55:1649-1655.

The NINDS tPA Stroke Study Group. Effect of intravenous tPA on ischemic stroke lesion size measured by CT: Results from the NINDS tPA Stroke Trial. Stroke 2000; 31: 2912-2919

Grotta JC, Welch KMA, Fagan SC, Lu M, Frankel MR, Brott T, Levine SR, and Lyden PD for the NINDS rt-PA Stroke Study Group. Clinical Deterioration Following Improvement in the NINDS rt-PA Stroke Trial. Stroke 2001; 32: 661-668.

Rowe AK, Frankel MR, Sanders KA. Stroke awareness among Georgia adults: epidemiology and considerations regarding measurement. Southern Medical Journal 2001:94:613-618.

Lyden P, Lu M, Kwiatkowski T, Frankel M, Levine S Broderick J, Brott T, and the NINDS rt-PA Stroke Study Group. Thrombolysis in patients with transient neurologic deficits. Neurology, 2001; 57:2125-2128.

Patel SC, Levine SR, Tilley BC, Grotta JC, Lu M, Frankel M, et al. for the National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Lack of Clinical Significance of Early Ischemic Changes on Computed Tomography in Acute Stroke. JAMA 2001; 286(22).

Qureshi AI, Mohammad Y, Suri MFK, Braimah J, Janardhan V, Guterman LR, Hopkins LN, Frankel MR. Cocaine use and hypertension are major risk factors for intracerebral hemorrhage in young African Americans. Ethnicity & Disease 2001;11:311-319.

Bruno A, Levine SR, Frankel MR, et al. Admission Glucose Level and Outcomes in the NINDS rt-PA Stroke Trial. Neurology 2002;59:669-674.

Meschia JF, Brott TG, Brown RG, Crook R, Frankel MR, Hardy J, Merino J, Rich SS, Silliman S, Worrall B. The Ischemic Stroke Genetics Study (ISGS) Protocol. BMC (BioMed Central) Neurology 2003, 3:4(8 July 2003).

IMS Study Investigators. Combined Intravenous and Intra-Arterial Recanalization for Acute Ischemic Stroke: The Interventional Management of Stroke Study. Stroke. 2004 Apr;35(4):904-11.

Hacke W, Donnan G, Fieschi C, Kaste M, von Kummer R, Broderick J, Brott T, Frankel M, Grotta JC, Haley EC Jr, Kwiatkowski T, Levine SR, Lewandowski C, Lu M, Lyden P, Marler JR, Patel S, Tilley BC, Albers G, Bluhmki E, Wilhelm M, Hamilton S. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 2004 Mar 6;363(9411):768-74.

Azran MS, Waljee A, Biousse V, Frankel M, Newman NJ. Episodic third nerve palsy with cryptococcal meningitis. Neurology. 2005 Feb 22;64(4):759-60.

Turan TN, Hertzberg V, Weiss P, McClellan W, Presley R, Krompf K, Karp H, and Frankel MR. Clinical Characteristics of Patients With Early Hospital Arrival After Stroke Symptom Onset. Journal of Stroke and Cerebrovascular Diseases, Vol. 14, No. 6 (November-December), 2005: pp 272-277.

Chimowitz MC, Lynn MS, Howlett-Smith H, Stern BJ, Hertzberg VS, Frankel MR, et al. Comparison of Warfarin and Aspirin for Symptomatic Intracranial Arterial Stenosis. N Engl J Med 2005; 352:1305-16.

Libman, R.B., Kwiatkowski T, Lyden P, Grotta J, Tilley BC, Fagan, S, Levine, S, Broderick, J, Lin, Y, Lewandowski C, and Frankel, M. Asymptomatic hemorrhagic transformation of cerebral infarction does not worsen long -- term outcome. Journal of Stroke and Cerebrovascular Diseases March - April, 2, 2005, 50-54.

Reeves MJ, Arora S, Broderick JP, Frankel M, Heinrich JP, Hickenbottom S, Karp H, LaBresh KA, Malarcher A, Moomaw CJ, Schwamm L, Weiss P; Paul Coverdell Prototype Registries Writing Group. Acute stroke care in the US: results from 4 pilot prototypes of the Paul Coverdell National Acute Stroke Registry. Stroke. 2005 Jun;36(6):1232-40.

The NINDS tPA Stroke Study Group. Recombinant t-PA for minor strokes Ann Emerg Med 2005;46(3):243-52.

Hertzberg V, Weiss P, Stern BJ, and Frankel MR. Family history associated with improved functional outcome following ischemic stroke. Neuroepidemiology. 2006;27(2):74-80

Kasner SE, Chimowitz MI, Lynn MJ, Howlett-Smith H, Stern BJ, Hertzberg VS, Frankel MR, Levine SR, Chaturvedi S, Benesch CG, Sila CA, Jovin TG, Romano JG, Cloft HJ; Warfarin Aspirin Symptomatic Intracranial Disease Trial Investigators. Predictors of stroke in the territory of a symptomatic intracranial arterial stenosis. Circulation 2006;113:555-563.

Wright DW, Kellermann AL, Hertzberg VS, Clark PL, Frankel MR, Goldstein FC, Salomone JP, Dent LL, Harris OA, Ander DS, Lowery DW, Patel MM, Denson DD, Gordon AB, Wald MM, Gupta S, Hoffman SW, and Stein DG. ProTECT: A Randomized Clinical Trial of Progesterone for Acute Traumatic Brain Injury. Ann Emerg Med. 2006 Sep 28.

Kasner SE, Lynn MJ, Chimowitz MI, Frankel MR, Howlett-Smith H, Hertzberg VS, Chaturvedi S, Levine SR, Stern BJ, Benesch CG, Jovin TG, Sila CA, Romano JG, for the Warfarin Aspirin Symptomatic Intracranial Disease (WASID) Trial Investigators. Warfarin vs aspirin for symptomatic intracranial stenosis: Subgroup analyses from WASID. Neurology 2006;67 1275-1278

Meschia JF, Case LD, Worrall BB, Brown RD Jr, Brott TG, Frankel M, Silliman S, Rich SS; Ischemic Stroke Genetics Study Group. Family history of stroke and severity of neurologic deficit after stroke. Neurology. 2006 Oct 24;67(8):1396-402.

Schwamm L, Reeves MJ, Frankel M. Designing a sustainable national registry for stroke quality improvement. Am J Prev Med 2006 Dec;31(6 Suppl 2):S251-7.

Reeves MJ, Broderick JP, Frankel M, LaBresh KA, Schwamm L, Moomaw CJ, Weiss P, Katzan I; Paul Coverdell Prototype Registries Writing Group, Arora S, Heinrich JP, Hickenbottom S, Karp H, Malarcher A, Mensah G, Reeves MJ.The Paul Coverdell National Acute Stroke Registry: initial results from four prototypes. Am J Prev Med 2006 Dec;31(6 Suppl 2):S202-9.

Matarín M, Brown WM, Scholz S, Simón-Sánchez J, Fung HC, Hernandez D, Gibbs JR, De Vrieze FW, Crews C, Britton A, Langefeld CD, Brott TG, Brown RD, Worrall BB, Frankel M, Silliman S, Case LD, Singleton A, Hardy JA, Rich SS, Meschia JF, A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release. Lancet Neurology 6:414-20 2007

Chaturvedi S, Turan TN, Lynn MJ, Kasner SE, Romano J, Cotsonis G, Frankel M, Chimowitz MI for the WASID Study Group. Risk factor status and vascular events in patients with symptomatic intracranial stenosis. Neurology 2007;69;2063-2068.

Labresh KA, Reeves MJ, Frankel MR, Albright D, and Schwamm LH. Hospital treatment of patients with ischemic stroke or transient ischemic attack with Get With The Guidelines. Archives of Internal Medicine. Feb 25, 2008;168(4):411-17.

Kleindorfer D, Miller R, Sailor-Smith S, Moomaw CJ, Khoury J, Frankel M. The challenges of community-based research: the beauty shop stroke education project. Stroke. 2008 Aug;39(8):2331-5.

Waddy SP, Cotsonis G, Lynn MJ, Frankel MR, Chaturvedi S, Williams JE, Chimowitz M. Racial Differences in Vascular Risk Factors and Outcomes of Patients With Intracranial Atherosclerotic Arterial Stenosis. Stroke. 2008 Oct 2. [Epub ahead of print]

Schwamm LH, Fonarow GC, Reeves MJ, Pan W, Frankel MR, Smith EE, Ellrodt G, Cannon CP, Liang L, Peterson E, Labresh KA. Get With the Guidelines-Stroke is associated with sustained improvement in care for patients hospitalized with acute stroke or transient ischemic attack. Circulation. 2009 Jan 6;119(1):107-15.

Schwamm LH, Audebert HJ, Amarenco P, Chumbler NR, Frankel MR, George MG, Gorelick PB, Horton KB, Kaste M, Lackland DT, Levine SR, Meyer BC, Meyers PM, Patterson V, Stranne SK, White CJ, and on behalf of the American Heart Association Stroke Council; Council on Epidemiology and Prevention; Interdisciplinary Council on Peripheral Vascular Disease; and the Council on Cardiovascular Radiology and Intervention . Recommendations for the Implementation of Telemedicine Within Stroke Systems of Care. A Policy Statement From the American Heart Association Stroke. Published online, May 7, 2009, doi:10.1161/STROKEAHA.109.192361

Rhoney DH, Coplin WM, Lin Y, Frankel M, Lyden PD, Levine SR.Time of day, outcome, and response to thrombolytic therapy: the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Trial experience. J Stroke Cerebrovasc Dis. 2010 Jan;19(1):40-8.

Famakin B, Weiss P, Hertzberg V, McClellan W, Presley R, Krompf K, Karp H, Frankel MR. Hypoalbuminemia predicts acute stroke mortality: Paul Coverdell Georgia Stroke Registry. J Stroke Cerebrovasc Dis. 2010 Jan;19(1):17-22

Schwamm LH, Reeves MJ, Pan W, Smith EE, Frankel MR, Olson D, Zhao X, Peterson E, Fonarow GC. Race/ethnicity, quality of care, and outcomes in ischemic stroke. Circulation. 2010 Apr 6;121(13):1492-501

Menon BK, Frankel MR, Liang L, Labresh KA, Ellrodt G, Hernandez AF, Fonarow GC, Schwamm LH, Smith EE; on behalf of the Get With The Guidelines–Stroke Steering Committee and Investigators Rapid Change in Prescribing Behavior in Hospitals Participating in Get With The Guidelines-Stroke After Release of the Management of Atherothrombosis With Clopidogrel in High-Risk Patients (MATCH) Clinical Trial Results. Stroke. 2010 Jul 15.

Reeves MJ, Gargano J, Maier KS, Broderick JP, Frankel M, LaBresh KA, Moomaw CJ, Schwamm L.. Patient-level and hospital-level determinants of the quality of acute stroke care: a multilevel modeling approach. Stroke 2010 Dec;41(12):2924-31.

Nahab F, Le A, Judd S, Frankel MR, Ard J, Newby PK, Howard VJ. Racial and geographic differences in fish consumption: the REGARDS study. Neurology. 2011 Jan 11;76(2):154-8. Epub 2010 Dec 22.

Anderson ER, Smith B, Ido M, Frankel M. Remote Assessment of Stroke Using the iPhone 4. J Stroke Cerebrovasc Dis. 2011 Oct 20. [Epub ahead of print] PMID:22018507

Nahab F, Kingston C, Frankel MR, Dion JE, Cawley CM, Mitchell B, Hammonds LP, Ayala L, Tong FC. Early Aggressive Medical Management for Patients with Symptomatic Intracranial Stenosis. J Stroke Cerebrovasc Dis. 2011 Jul 25. [Epub ahead of print]

Gupta R, Horev A, Nguyen T, Gandhi D, Wisco D, Glenn BA, Tayal AH, Ludwig B, Terry JB, Gershon RY, Jovin T, Clemmons PF, Frankel MR, Cronin CA, Anderson AM, Hussain MS, Sheth KN, Belagaje SR, Tian M, Nogueira RG. Higher volume endovascular stroke centers have faster times to treatment, higher reperfusion rates and higher rates of good clinical outcomes. J Neurointerv Surg. 2012 Jul 25. [Epub ahead of print]

SPS3 Investigators, Benavente OR, Hart RG, McClure LA, Szychowski JM, Coffey CS, Pearce LA. Effects of clopidogrel added to aspirin in patients with recent lacunar stroke. N Engl J Med. 2012 Aug 30;367(9):817-25.

Sun CH, Nogueira RG, Glenn BA, Connelly K, Zimmermann S, Anda K, Camp D, Frankel MR, Belagaje SR, Anderson AM, Isakov AP, Gupta R. "Picture to puncture": a novel time metric to enhance outcomes in patients transferred for endovascular reperfusion in acute ischemic stroke. Circulation. 2013 Mar 12;127(10):1139-48.

Horn CM, Sun CH, Nogueira RG, Patel VN, Krishnan A, Glenn BA, Belagaje SR, Thomas TT, Anderson AM, Frankel MR, Schindler KM, Gupta R. Endovascular Reperfusion and Cooling in Cerebral Acute Ischemia (ReCCLAIM I). J Neurointerv Surg. 2013 Mar 6. [Epub ahead of print]

Rangaraju S, Owada K, Noorian R, Nogueira RG, Nahab F, Glenn BA, Belagaje SR, Anderson AM, Frankel MR, Gupta R. Comparison of Final Infarct Volumes in Patients Who Received Endovascular Therapy or Intravenous Thrombolysis for Acute Intracranial Large-Vessel Occlusions. JAMA Neurol, Published online May 13, 2013. [doi:10.1001/jamaneurol.2013.413.]

Woo D, Rosand J, Kidwell C, McCauley J, Osborne J, Brown MW, West SE, Rademacher EW, Waddy S, Roberts JN, Koch S, Gonzales NR, Sung G, Kittner S, Birnbaum L, Frankel M, Testai FE, Hall C, Elkind M, Flaherty M, Coull B, Chong JY, Warwick T, Malkoff M, James ML, Ali LK, Worrall B, Jones F, Watson T, Leonard A, Martinez R, Sacco R and Langefeld CD. The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) Study Protocol. Stroke, published online Sept 10, 2013.

Ivan C. Rokos, Lee H. Schwamm, Madeleine Konig, Mary-Beth Malcarney, Katie B. Horton, Jeffrey Ranous, A. Gray Ellrodt, Steven A. Farmer, Michael R. Frankel, T. Bruce Ferguson, David C. Goff, Jr, Loren Hiratzka, Alice K. Jacobs on behalf of the American Heart Association Advocacy Coordinating Committee. Variable Impact of State Legislative Advocacy on Registry Participation and Regional Systems of Care Implementation: A Policy Statement From the American Heart Association. Circulation. Published on line Sept 16, 2013.

Kass-Hout T, Kass-Hout O, Sun CH, Kass-Hout T, Belagaje S, Anderson A, Frankel M, Gupta R, Nogueira R. Clinical, angiographic and radiographic outcome differences among mechanical thrombectomy devices: initial experience of a large-volume center. J Neurointerv Surg. 2014 Mar 21. doi: 10.1136/neurintsurg-2013-011037. [Epub ahead of print]

Bian F, Simon RP, Li Y, David L, Wainwright J, Hall CL, Frankel M, Zhou A. Nascent proteomes in peripheral blood mononuclear cells as a novel source for biomarker discovery in human stroke. Stroke. 2014 Apr;45(4):1177-9. doi: 10.1161/STROKEAHA.113.004576. Epub 2014 Feb 20.

Sun CH, Connelly K, Nogueira RG, Glenn BA, Zimmermann S, Anda K, Camp D, Gaunt S, Pallard H, Eckenroth M, Frankel MR, Belagaje SR, Anderson AM, Nahab F, Yepes M, Gupta R. ASPECTS decay during inter-facility transfer predicts patient outcomes in endovascular reperfusion for ischemic stroke: a unique assessment of dynamic physiologic change over time. J Neurointerv Surg. 2014 Mar 26. doi: 10.1136/neurintsurg-2013-011048. [Epub ahead of print]

Belagaje SR, Sun CH, Nogueira RG, Glenn BA, Wuermser LA, Patel V, Frankel MR, Anderson AM, Thomas TT, Horn CM, Gupta R. Discharge disposition to skilled nursing facility after endovascular reperfusion therapy predicts a poor prognosis. J Neurointerv Surg. 2014 Jan 17. doi: 10.1136/neurintsurg-2013-011045. [Epub ahead of print]

Derdeyn CP, Chimowitz MI, Lynn MJ, Fiorella D, Turan TN, Janis LS, Montgomery J, Nizam A, Lane BF, Lutsep HL, Barnwell SL, Waters MF, Hoh BL, Hourihane JM, Levy EI, Alexandrov AV, Harrigan MR, Chiu D, Klucznik RP, Clark JM, McDougall CG, Johnson MD, Pride GL Jr, Lynch JR, Zaidat OO, Rumboldt Z, Cloft HJ; Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial Investigators. Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial. Lancet. 2014 Jan 25;383(9914):333-41. doi: 10.1016/S0140-6736(13)62038-3. Epub 2013 Oct 26.

Rangaraju S, Liggins JT, Aghaebrahim A, Streib C, Sun CH, Gupta R, Nogueira R, Frankel M, Mlynash M, Lansberg M, Albers G, Jadhav A, Jovin TG. Pittsburgh outcomes after stroke thrombectomy score predicts outcomes after endovascular therapy for anterior circulation large vessel occlusions. Stroke. 2014 Aug;45(8):2298-304. PMID: 25005445

Rangaraju S, Aghaebrahim A, Streib C, Sun CH, Ribo M, Muchada M, Nogueira R, Frankel M, Gupta R, Jadhav A, Jovin TG. Pittsburgh Response to Endovascular therapy (PRE) score: optimizing patient selection for endovascular therapy for large vessel occlusion strokes. J Neurointerv Surg. 2014 Oct 15, PMID: 25320054

Pearce LA, McClure LA, Anderson DC, Jacova C, Sharma M, Hart RG, Benavente OR; SPS3 Investigators. Effects of long-term blood pressure lowering and dual antiplatelet treatment on cognitive function in patients with recent lacunar stroke: a secondary analysis from the SPS3 randomised trial. Lancet Neurol. 2014 Dec;13(12):1177-85.

Wright DW, Yeatts SD, Silbergleit R, Palesch YY, Hertzberg VS, Frankel M, Goldstein FC, Caveney AF, Howlett-Smith H, Bengelink EM, Manley GT, Merck LH, Janis LS, Barsan WG; NETT Investigators. Very early administration of progesterone for acute traumatic brain injury.N Engl J Med. 2014 Dec 25;371(26):2457-66.

Ido MS, Bayakly R, Frankel M, Lyn R, Okosun IS. Administrative data linkage to evaluate a quality improvement program in acute stroke care, Georgia, 2006-2009. Prev Chronic Dis. 2015 Jan 15;12:E05.

Kass-Hout T, Kass-Hout O, Sun CH, Kass-Hout T, Belagaje SR, Anderson AM, Frankel MR, Gupta R, Nogueira RG. Periprocedural cost-effectiveness analysis of mechanical thrombectomy for acute ischemic stroke in the stent retriever era. Interv Neurol. 2015 Mar;3(2):107-13.

Kass-Hout T, Kass-Hout O, Sun CH, Kass-Hout T, Belagaje S, Anderson A, Frankel M, Gupta R, Nogueira R. Clinical, angiographic and radiographic outcome differences among mechanical thrombectomy devices: initial experience of a large-volume center. J Neurointerv Surg. 2015 Mar;7(3):176-81

Haussen DC, Lima A, Frankel M, Anderson A, Belagaje S, Nahab F, Rangaraju S, Nogueira RG. Sulcal effacement with preserved gray-white junction: a sign of reversible ischemia. Stroke. 2015 Jun;46(6):1704-6.

Kass-Hout T, Kass-Hout O, Sun CH, Kass-Hout T, Belagaje SR, Anderson AM, Frankel MR, Gupta R, Nogueira RG. Periprocedural cost-effectiveness analysis of mechanical thrombectomy for acute ischemic stroke in the stent retriever era. Interv Neurol. 2015 Mar;3(2):107-13

Rangaraju S, Streib C, Aghaebrahim A, Jadhav A, Frankel M, Jovin TG. Relationship Between Lesion Topology and Clinical Outcome in Anterior Circulation Large Vessel Occlusions. Stroke. 2015 Jul;46(7):1787-92.

Rebello LC, Haussen DC, Belagaje S, Anderson A, Frankel M, Nogueira RG. Endovascular Treatment for Acute Ischemic Stroke in the Setting of Anticoagulation. Stroke. 2015 Oct 15. pii: STROKEAHA.115.011285. [Epub ahead of print]

Sheth KN, Martini SR, Moomaw CJ, Koch S, Elkind MS, Sung G, Kittner SJ, Frankel M, Rosand J, Langefeld CD, Comeau ME, Waddy SP, Osborne J, Woo D. Prophylactic Antiepileptic Drug Use and Outcome in the Ethnic/Racial Variations of Intracerebral Hemorrhage Study. Stroke. 2015 Oct 15. pii: STROKEAHA.115.010875. [Epub ahead of print]

Noorian AR, Rangaraju S, Sun CH, Owada K, Nahab F, Belagaje SR, Anderson AM, Frankel MR, Nogueira RG. Endovascular Therapy in Strokes with ASPECTS 5-7 May Result in Smaller Infarcts and Better Outcomes as Compared to Medical Treatment Alone. Interv Neurol. 2015 Oct;4(1-2):30-7. PMID: 26600794

Nogueira RG, Haussen DC, Dehkharghani S, Rebello LC, Lima A, Bowen M, Belagaje S, Anderson A, Frankel M. Large Volumes of Critically Hypoperfused Penumbral Tissue Do Not Preclude Good Outcomes After Complete Endovascular Reperfusion: Redefining Malignant Profile. Stroke. 2016 Jan;47(1):94-8. Epub 2015 Nov 24. PMID: 26604248

Ido MS, Okosun IS, Bayakly R, Clarkson L, Lugtu J, Floyd S, Krompf K, Frankel M. Door to Intravenous Tissue Plasminogen Activator Time and Hospital Length of Stay in Acute Ischemic Stroke Patients, Georgia, 2007-2013. J Stroke Cerebrovasc Dis. 2016 Apr;25(4):866-71. Epub 2016 Feb 4. PMID: 26853143

Grigoryan M, Haussen DC, Hassan AE, Lima A, Grossberg J, Rebello LC, Tekle W, Frankel M, Nogueira RG. Endovascular Treatment of Acute Ischemic Stroke Due to Tandem Occlusions: Large Multicenter Series and Systematic Review. Cerebrovasc Dis. 2016 Feb 17;41(5-6):306-312. [Epub ahead of print] PMID: 26881779

Meller R, Pearson AN, Hardy JJ, Hall CL, McGuire D, Frankel MR, Simon RP Blood transcriptome changes after stroke in an African American population. Ann Clin Transl Neurol. 2016 Jan 15;3(2):70-81PMID: 26900583

Rebello LC, Haussen DC, Grossberg JA, Belagaje S, Lima A, Anderson A, Frankel MR, Nogueira RG. Early Endovascular Treatment in Intravenous Tissue Plasminogen Activator-Ineligible Patients. Stroke. 2016 Apr;47(4):1131-4. PMID: 26906918

Rangaraju S, Frankel M, Jovin TG. Prognostic Value of the 24-Hour Neurological Examination in Anterior Circulation Ischemic Stroke: A post hoc Analysis of Two Randomized Controlled Stroke Trials. Interv Neurol. 2016 Mar;4(3-4):120-9. PMID: 27051408

Nahab F, Pearson K, Frankel MR, Ard J, Safford MM, Kleindorfer D, Howard VJ, Judd S. Dietary fried fish intake increases risk of CVD: the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Public Health Nutr. 2016 Jun 24:1-10. [Epub ahead of print] PMID: 27338865

Lima FO, Silva GS, Furie KL, Frankel MR, Lev MH, Camargo ÉC, Haussen DC, Singhal AB, Koroshetz WJ, Smith WS, Nogueira RG. Field Assessment Stroke Triage for Emergency Destination: A Simple and Accurate Prehospital Scale to Detect Large Vessel Occlusion Strokes. Stroke. 2016 Aug;47(8):1997-2002. Epub 2016 Jun 30. PMID: 27364531

Lima A, Haussen DC, Rebello LC, Dehkharghani S, Grossberg J, Grigoryan M, Frankel M, Nogueira RG. Endovascular Therapy for Large Vessel Stroke in the Elderly: Hope in the New Stroke Era. Cerebrovasc Dis. 2016 Jul 26;42(5-6):421-427. [Epub ahead of print. PMID: 27454483

Haussen DC, Dehkharghani S, Rangaraju S, Rebello LC, Bouslama M, Grossberg JA, Anderson A, Belagaje S, Frankel M, Nogueira RG. Automated CT Perfusion Ischemic Core Volume and Noncontrast CT ASPECTS: Correlation and Clinical Outcome Prediction in Large Vessel Stroke. Stroke. 2016 Aug 9. pii: STROKEAHA.116.014117. [Epub ahead of print] PMID: 27507858

Prater A, Bowen M, Pavich E, Hawkins CM, Safdar N, Fountain J, Anderson A, Frankel M, Dehkharghani S. Enhancing Workflow Analysis in Acute Stroke Patients Using Radiofrequency Identification and Infrared-based Real-Time Location Systems. J Am Coll Radiol. 2016 Aug 28. [Epub ahead of print] PMID: 27577591

Rangaraju S, Jovin TG, Frankel M, Schonewille WJ, Algra A, Kappelle LJ, Nogueira RG; BASICS Study Group. Neurologic Examination at 24 to 48 Hours Predicts Functional Outcomes in Basilar Artery Occlusion Stroke. Stroke. 2016 Oct;47(10):2534-40. PMID: 27586683

Haussen DC, Bouslama M, Grossberg JA, Anderson A, Belagage S, Frankel M, Bianchi N, Rebello LC, Nogueira RG. Too good to intervene? Thrombectomy for large vessel occlusion strokes with minimal symptoms: an intention-to-treat analysis. J Neurointerv Surg. 2016 Sep 2. [Epub ahead of print] PMID: 27589861