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Marilyn G. Foreman

Marilyn G. Foreman, MD, MS

Dr. Foreman is a Professor of Clinical Medicine at Morehouse School of Medicine in Atlanta, GA, USA. She initiated the Pulmonary and Critical Care Medicine clinical services at Grady Memorial Hospital for the Internal Medicine Residency Program in 1992. She is a member of several professional societies including the American Thoracic Society, CHEST, and the Society for Research on Nicotine and Tobacco. Trained in Respiratory, Genetic, and Environmental Epidemiology at the Channing Institute (now the Channing Division for Network Medicine), Brigham and Women’s Hospital, Boston, MA, her research focuses on chronic obstructive pulmonary disease (COPD) and tobacco-related health disparities. Her current interest is identifying predictors of smoking cessation in high risk groups. She is a site PI for the Genetic Epidemiology of COPD (COPDGene) Study where investigations have shown that early-onset COPD is associated with female sex, maternal factors, and African American race; higher-genetically-determined African ancestry is associated with lower lung function; and in comparison to individuals who do not possess Z alleles, heterozygosity for alpha-1 antitrypsin is associated with greater loss of lung function and increased radiographic emphysema in Non-Hispanic whites and Non-Hispanic African Americans with a history of tobacco smoking.

Specialties

  • Critical Care Medicine
  • Internal Medicine

Board Certifications

  • ABMS Internal Medicine

Fellowships

  • R. Adams Cowley Shock Trauma Center

Affiliations

  • Morehouse

Education & Training

  • Medical School: Meharry Medical College School of Medicine
  • Internship: Greater Baltimore Medical Center
  • Residency: Greater Baltimore Medical Center

Honors & Awards

Faculty of the Year, Department of Medicine, Internal Medicine Residency Program 2015

Leonard Tow Humanism in Medicine 2017

Publications

Foreman MG, Ten Hoor T, Brown LAS, Moss M: The effects of chronic hepatic dysfunction on pulmonary glutathione homeostasis. Alcoholism: Clinical and Experimental Research 2002; 26(12):1840-1845 PMID 12500108 2.

Foreman MG, Mannino DM, Moss M. Cirrhosis as a risk factor for sepsis and death: analysis of the National Hospital Discharge Survey. Chest 2003;124:1016–1020. PMID 1290032 3.

Tacconelli E, Carmeli Y, Aizer A, Ferreira G, Foreman MG, D’Agata E. Mupirocin prophylaxis to prevent Staphylococcus aureus infections in dialysis patients: a meta analysis. Clin Infectious Dis 2003;37:1629-1638. PMID: 14689344 4.

Foreman MG, Mannino DM, Kamugisha L, Westney GE. Hospitalization for patients with sarcoidosis: 1979 – 2000. Sarcoidosis, Vasculitis, and Diffuse Lung Diseases 2006; 23, 124-129 PMID: 17937108 5.

Dransfield MT, Washko GR, Foreman M, Estepar RSJ, Reilly J, Bailey WC. Gender differences in the severity of CT emphysema in COPD. Chest 2007;132(2):464-470 PMID: 17573503 6.

Foreman MG, DeMeo DL, Hersh CP, Reilly JJ, Silverman EK. Clinical determinants of exacerbations in patients with severe early-onset COPD. Eur Respir J 2007; 30(6):1124-1130 PMID 17715170 7.

Foreman MG, DeMeo DL, Hersh CP, Carey VJ, Fan VS, Reilly JJ, Shapiro SD, Silverman EK. Polymorphic variation in surfactant protein B is associated with COPD exacerbations. Eur Respir J 2008; 32(4):938-944 PMID:18550614 PMCID: PMC2761762 8.

He J-Q*, Foreman MG*, Shumansky K, Zhang X, Akhabir L, Sin DD, Man SFP, DeMeo DL, Litonjua AA, Silverman EK, Connett JE, Anthonisen NR, Wise RA, Pare PD, Sandford AJ. Associations of IL6 polymorphisms with lung function decline and COPD. Thorax 2009 Aug, 64(8):698-704 PMID:19359268 PMCID: PMC2859187 9.

Foreman MG, Pillai S, DeMeo DL, Kong X, Hersh CP, Carey VJ, Litonjua AA, Fan VS, Shapiro SD, Tal-Singer R, Silverman EK. Polymorphisms in the surfactant protein D gene are associated with COPD. Am J Respir Cell Mol Biol 2011 Mar;44(3):316-322 PMID: 20448057 PMCID: PMC3095932 10.

Wan ES, DeMeo DL, Hersh CP, Shapiro SD, Rosiello RA, Sama SR, Fuhlbrigge AL, Foreman MG, Silverman EK. Clinical predictors of frequent exacerbations in subjects with severe chronic obstructive pulmonary disease (COPD). Respir Med 2011 Apr; 104(4):588-594 PMID:21145719 PMCID: PMC3046312 11.

Han MK, Curran-Everett D, Dransfield MT, Criner G, Zhang L, Murphy JR, Hansel NN, DeMeo DL, Hanania NA, Regan E, Make B, Martinez FJ, Westney G, Foreman MG. Racial differences in quality of life in COPD. Chest 2011 Nov;140(5):1169-1176 PMID: 21636665 PMCID: PMC3205846 12.

Han MK, Foreman MG. Racial differences in quality of life in patients with COPD, reply. Chest 2011;140(5)1169-1176 13.

Foreman MG, Zhang L, Murphy J, Hansel NN, Make B, Hokanson JE, Washko G, Regan EA, Crapo JD, Silverman EK, Demeo DL; the COPDGene Investigators. Early–onset COPD is associated with female gender, maternal factors, and African American race in the COPDGene Study. Am J Respir Crit Care Med. 2011 Aug 15;184(4):414-420. PMID: 21562134 PMCID: PMC3175544 14.

Aldrich MD, Kumar R, Colangelo LA, Williams LK, Sen S, Kritchevsky SB, Meibohm B, Galanter J, Hu D, Gignoux CR, Liu Y, Harris TB, Ziv E, Zmuda J, Garcia M, Leak TS, Foreman MG, Smith LJ, Fornage M, Liu K, Burchard EG for the Health ABC and CARDIA Studies. Genetic ancestry-smoking interactions and lung function in African Americans: a cohort study, PLoS ONE 2012;7(6):e39541 PMID: 22737244 PMCID: PMC3380861 15.

Hansel NN, Washko GR, Foreman MG, Han MK, Hoffman EA, DeMeo DL, Barr RG, Van Beek EJR, Kazerooni EA, Wise RA, Brown RH, Black-Shinn J, Hokanson JE, Hanania NA, Make B, Silverman EK, Crapo JD, Dransfield MT, for the COPDGene Investigators. Racial Differences in CT phenotypes in COPD. COPD 2013 Feb;10(1):20-27 PMID:23413893 PMCID: PMC4321889 16.

Bhatt SP, Young-il K, Wells JM, Bailey WC, Ramsdell JW, Foreman MG, Jensen RL, Stinson DA, Wilson CG, Lynch DA, Make BJ, Dransfield MT. FEV1/FEV6 to diagnose airflow obstruction: comparisons with computed tomography and morbidity indices. Annals of the American Thoracic Society 2014 Mar;11(3):335-341 PMID:24450777 PMCID: PMC4028741 17.

Castaldi PJ, Dy J, Ross J, Chang Y, Washko GR, Curran-Everett D, Williams A, Lynch DA, Make BJ, Crapo JD, Bowler RP, Regan EA, Hokanson JE, Kinney GL, Han MK, Soler X, Ramsdell JW, Barr RG, Foreman M, van Beek E, Casaburi R, Criner GJ, Lutz SM, Rennard SI, Santorico S, Sciurba FC, Demeo DL, Hersh CP, Silverman EK, Cho MH. Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema. Thorax 2014 May;69(5):416-423 PMID: 24563194 PMCID: PMC4004338 18.

Bhatt SP, Wells JM, Kim V, Criner GJ, Hersh CP, Hardin M, Bailey WC, Nath H, Young il-Kim, Foreman MG, Stinson D, Wilson CG, Silverman EK, Make BJ, Dransfield MT. Radiological correlates and clinical implications of paradoxical lung function response to β2 agonists: an observational study. Lancet Respir Med 2014 Nov;2(11):911-918 PMID:25217076 PMCID: PMC4306040 19.

Putcha N, Han M, Martinez C, Foreman M, Anzueto A, Casaburi R, Cho MH, Hanania N, Hersh C, Kinney C, Make B, Steiner R, Lutz S, Thomashow B, Williams A, Bhatt S, Beaty T, Bowler R, Ramsdell J, Curtis J, Everett D, Hokanson J, Lynch D, Sutherland E, Silverman E, Crapo J, Wise R, Regan E, Hansel N. Comorbidities of COPD have a Major impact on clinical outcomes, particularly in African Americans. Chronic Obstr Pulm Dis (Miami) 2014;1(1):105-114 PMID:25695106 PMCID: PMC4329763

Criner GJ, Bourbeau J, Diekemper RL, Ouellette DR, Goodridge D, Hernandez P, Curren K, Balter MS, Bhutani M, Camp PG, Celli BR, Dechman G, Dransfield MT, Fiel SB, Foreman MG, Hanania NA, Ireland BK, Marchetti N, Marciniuk DD, Mularski RA, Ornelas J, Road JD, Stickland MK. Executive summary: prevention of acute exacerbation of chronic obstructive pulmonary disease: American College of Chest Physicians and Canadian Thoracic Society Guideline. Chest 2014 Oct 16 PMID: 25320966 PMCID: PMC4388123 21.

Criner GJ, Bourbeau J, Diekemper RL, Ouellette DR, Goodridge D, Hernandez P, Curren K, Balter MS, Bhutani M, Camp PG, Celli BR, Dechman G, Dransfield MT, Fiel SB, Foreman MG, Hanania NA, Ireland BK, Marchetti N, Marciniuk DD, Mularski RA, Ornelas J, Road JD, Stickland MK. Prevention of acute exacerbations of chronic obstructive pulmonary disease: American College of Chest Physicians and Canadian Thoracic Society Guideline. Chest 2014 Oct 16 PMID:25321320 PMCID: PMC4388124 22.

Hobbs BD, Foreman MG, Bowler R, Jacobson F, Make BJ, Castaldi PJ, San José Estépar R, Silverman EK, Hersh CP and the COPDGene Investigators. Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease. Ann Am Thorac Soc 2014 Nov;11(9):1387-1394 PMID:25295410

Parker MM*, Foreman MG*, Abel HJ, Mathias RA, Hetmanski JB, Crapo JD, Silverman EK, Beaty TH. Admixture mapping identifies a quantitative trait locus associated with lung function in the COPDGene Study. Genetic Epidemiology 2014 Nov;38(7):652-659 PMID: 25112515 PMCID:PMC4190160

Hersh CP, Make BJ, Lynch D, Barr G, Bowler RP, Castaldi PJ, Cho MH, Foreman MG, Han MK, Harshfield BJ, Hokanson JE, Lutz S, Ramsdell JW, Regan EA, Rennard SI, Schroeder JD, Sciurba FC, van Beek EJR, Silverman EK, Crapo JD. Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus. BMC Pulm Med 2014 Oct 24;14:164 PMID: 25341556 PMCID: PMC4216374 25.

Putcha N, Puhan MA, Drummond MB, Han MK, Regan EA, Hanania NA, Martinez C, Foreman M, Bhatt SP, Make B, Ramsdell J, DeMeo D, Barr RG, Rennard SI, Martinez, F, Silverman EK, Crapo J, Wise RA, Hansel NN. A simplified score to quantify comorbidity in COPD. PLoS ONE 2014 Dec 16;19(12):e114438. doi: 10.1371/journal.pone.0114438. eCollection 2014. PMID: 25514500 PMCID: PMC4267736 26.

Wan ES, Qiu W, Carey VJ, Morrow J, Bacherman H, Foreman MG, Hokanson JE, Bowler RP, Crapo JD, DeMeo DL. Smoking associated site specific differential methylation in buccal mucosa in the COPDGene Study. Am J Respir Mol Cell Biol 2015 Aug;53(2):246-54 PMID: 25517428 PMCID: PMC4566042 27.

Park SJ, Foreman MG, DeMeo DL, Bhatt SP, Hansel NN, Wise RA, Soler X, Bowler RP. Menthol cigarette smoking in COPDGene cohort: relationship with COPD, comorbidities, and CT metrics. Respirology 2015 Jan 20(1);108-114: PMID: 25328036 PMCID: PMC4415502 28.

Burchard EG, Oh SS, Foreman MG, Celedón J. Moving towards true inclusion of racial/ethnic minorities in federally funded studies: a key step to achieve respiratory health equality in the United States. Am J Respir Crit Care Med 2015 Mar 1;191(5):514-521 PMID: 25584658 PMCID: PMC4384771 29.

Jaramillo JD, Wilson C, Stinson DJ, Lindsay SE, Lutz S, Foreman MG, Soler X, Lynch DA, Hokanson JE, DeMeo DL, Wan ES, MacDonald M-L, Washko GR, Bowler RP, Bon J, Silverman EK, Arnold B, Make B, Lane NE, Genant HK, Crapo JD, Regan EA. Bone density and vertebral fractures in smokers. Ann Am Thorac Soc 2015 May;12(5):648-56 PMID: 25719895 PMC: PMC4418341 30.

Hardin M, Foreman M, Dransfield MT, Hansel N, Han HK, Cho MH, Bhatt SP, Ramsdell J, Lynch D, Curtis JL, Silverman EK, Washko G, DeMeo D. Sex-specific features of emphysema among current and former smokers with COPD. 2016 Jan;47(1):104-12. doi: 10.1183/13993003.00996-2015. Epub 2015 Nov 5. PMID: 26541532 PMCID: PMC5374719 31.

Lutz SM, Cho MH, Young K, Hersh CP, Castaldi P, McDonald ML, Regan E, Mattheisen M, DeMeo DL, Parker M, Foreman M, Make BJ, Jensen RL, Casaburi R, Lomas DA, Bhatt SP, Bakke P, Gusvik A, Crapo JD, Beaty TH, Laird N, Lange C, Hokanson JE, Silverman EK, ECLIPSE Investigators, and COPDGene Investigators. (2015) A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genetics 2015 Dec 3;16(1):138 PMID: 26634245 PMC: PMC4668640 32.

Checkley W, Foreman MG, Bhatt S, Dransfield M, Han M, Hanania NA, Hansel NN, Regan EA, Wise RA and the COPDGene Study Investigators. Differences between absolute and predicted values of forced expiratory volumes to classify ventilatory impairment in chronic obstructive pulmonary disease. Respir Med (2015). PMID: 26712569 33.

Bhatt SP, Terry LJ, Nath H, Zach JA, Tschirren J, Bolding MS, Stinson DS, Wilson CG, Curran-Everett D, Lynch DA, Putcha N, Soler X, Wise RA, Washko GR, Hoffman EA, Foreman MG, Dransfield MT. Association between expiratory central airway collapse and respiratory outcomes among smokers. JAMA 2016 Feb 2;315(5):498-505 PMID: 26836732 34.

Mathias RA, Taub MA, Gignoux CR, Fu W, Musharoff S, O'Connor TD, Vergara C, Torgerson DG, Pino-Yanes M, Shringarpure SS, Huang L, Rafaels N, Boorgula MP, Johnston HR, Ortega VE, Levin AM, Song W, Torres R, Padhukasahasram B, Eng C, Mejia-Mejia DA, Ferguson T, Qin ZS, Scott AF, Yazdanbakhsh M, Wilson JG, Marrugo J, Lange LA, Kumar R, Avila PC, Williams LK, Watson H, Ware LB, Olopade C, Olopade O, Oliveira R, Ober C, Nicolae DL, Meyers D, Mayorga A, Knight-Madden J, Hartert T, Hansel NN, Foreman MG, Ford JG, Faruque MU, Dunston GM, Caraballo L, Burchard EG, Bleecker E, Araujo MI, Herrera-Paz EF, Gietzen K, Grus WE, Bamshad M, Bustamante CD, Kenny EE, Hernandez RD, Beaty TH, Ruczinski I, Akey J, and Barnes KC and CAAPA. A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome. Nature Communications 2016 Oct 11;7:1252235. PMID: 27725671 35.

Keene JD, Jacobson S, Kechris K, Kinney GL, Foreman MG, Doerschuk CM, Make BJ, Curtis JL, Rennard SI. Barr RG, Bleecker ER, Kanner RE, Kleerup EC, Hansel NN, Woodruff PG, Han MK, Paine R, Martinez FJ. Bowler RP, O’Neal WK, for the COPDGene and SPIROMICS Investigators. Biomarkers predictive of exacerbations in the SPIROMICS and COPDGene cohorts. Am J Respir Crit Care Med 2016 Aug 31 PMID: 27579823 PMCID: PMC5378424 36.

Foreman MG, Wilson C, DeMeo DL, Hersh CP, Beaty TH, Cho MH, Ziniti J, Curran-Everett D, Criner G, Hokanson JE, Brantly M, Rouhani FN, Sandhaus RA, Crapo JD, Silverman EK. Alpha-1 antitrypsin PI MZ genotype is associated with COPD in two racial groups. Ann Am Thorac Soc 2017, Apr 5 PMID: 28380308 37.

Westney G*, Foreman MG*, Xu J, Henriques-Forsythe M, Flenaugh E, rust G. Impact of comorbidities among Medicaid enrollees with chronic obstructive pulmonary disease. Prev Chronic Dis, 2017 Apr 13:14:E31 PMID: 28409741

Chen L, Zawartailo L, Piasecki T, Kaprio J, Foreman M, Elliott H, David S, Bergen A, Baurley J, Tyndale R, Baker T, Bierut L. Leveraging genomic data in smoking cessation trials in the era of Precision Medicine. Nicotine Tob Res 2017, May 12. May 12. https://doi.org/10.1093/ntr/ntx097 PMID: 28498934 39.

Saccone N, Baurley J, Bergen A, David S, Foreman M, Kapprio J, Piasecki T, Relton C, Zawartailo L, Bierut L, Chen L. The value of biosamples in smoking cessation trials: a review of genetic, metabolomic, and epigenetic findings, accepted, Nicotine Tob Res 2017, May 3. https://doi.org/10.1093/ntr/ntx097 PMID: 28472521 40.

Bowler RP, Hansel NN, Jacobson S, Barr RG, Make BJ, Han MK, O’Neal WK, Oelsner EC, Casaburi R, Barjaktarevic I, Cooper C, Foreman M, Wise RA, DeMeo DL, Silverman EK, Bailey W, Harrington KF, Woodruff PG, Drummond B, and the COPDGene and SPIROMICS Investigators. Electronic cigarette use in US adults at risk for or with COPD: analysis from two observational cohorts. J Gen Intern Med, published online 07 September 2017 doi: 10.1007/s11606-017-4150-7 41.

Parulekar AD, Martinez C, Tsai C, Locantore N, Atik MA, Yohannes AM, Kao C, Al-Azzawi H, Mohsin A, Wise RA, Foreman MG, Demeo D, Regan EA, Make BJ, Boriek AM, Hanania NA. Examining the effects of age on health outcomes of COPD: results from the COPDGene and ECLIPSE Cohorts. J Amer Med Dir Assoc, 2017, accepted 9/29/2017 https://www.ncbi.nlm.nih.gov/sites/myncbi/marilyn.foreman.1/bibliography/10288420/public/?sort=date&direction=ascending