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David W. Wright

David W. Wright, MD

Interim Chair of Emergency Medicine

Dr. David Wright is the Interim Chair and Professor of emergency medicine, and Director of Emergency Neurosciences, at Emory University’s School of Medicine. Dr. Wright is actively involved in both the preclinical and clinical assessment of traumatic brain injury (TBI) and stroke. He was the Principal Investigator of the NIH funded multicenter Phase III clinical trial, ProTECT™ (Progesterone for TBI, experimental clinical treatment). He is the Principal Investigator of the Emory Hub for the Neurological Emergencies Treatment Trials Network and for the new SIREN network. He also is the Co-PI of the Emory hub for NIH funded NINDS StrokeNet network. He participates in numerous concussion research and technology development endeavors. He has served on multiple NINDS grant review panels over the past 15 years.

Board Certifications

  • ABMS Emergency Medicine

Affiliations

  • Emory

Education & Training

  • Medical School: University of Alabama at Birmingham
  • Residency: University of Cincinnati College of Medicine

Honors & Awards

Fellow Status in the American College of Emergency Physicians (FACEP); 2000

Society for Academic Emergency Medicine Young Investigator Award; 2001

Healthcare Hero Award, Healthcare Innovations, Atlanta Business Chronicle 2008

Alpha Omega Alpha Honor Society Membership; 2011

Society for Academic Emergency Medicine (SAEM) Research Fellowship Program; 2011

Finalist for Atlanta Magazine Groundbreakers Award; 2013

Woodruff Leadership Academy Class of 2015

Deans Faculty Excellence Recognition; 2015

Emory School of Medicine Mentoring Award Finalist - 2017

Publications

Wright DW, Mayne R: Vitreous Humor of Chicken Contains Two Fibrillar Systems: An Analysis of Their Structure. Journal of Ultrastructure and Molecular Structure Research 1988; 100: 224-234. PMID: 2468720 2.

Hunsinger RN, Wright D: A Characterization of the Acute Cardiopulmonary Toxicity of Fenfluramine in the Rat. Pharmacological Research, 1990; 22 No.3: 371 – 378. PMID: 2367283 3.

Shimokomaki M, Wright DW, Irwin MH, Mayne R, Van Der Rest M: Crosslinks in Cartilage Collagen Fibers. CONBRAP, 1990; 423 - 432 4.

Shimokomaki M, Wright DW, Irwin MH, Van Der Rest M, Mayne R: The Structure and Macromolecular Organization of Type IX Collagen in Cartilage. Structure, Molecular Biology, and Pathology of Collagen, Annals of New York Academy of Sciences, 1990; 580: 1 - 7. PMID: 2186687 5.

Brewton RG, Wright DW, Mayne R: Structural and Functional Comparison of Type IX Collagen-Proteoglycan from Chicken Cartilage and Vitreous Humor. The Journal of Biological Chemistry, 1991; 266 No.8: 4752 - 4757. PMID: 2002024 6.

Mayne R, Brewton RG, Wright DW, Ren ZX: Morphological and Biochemical Studies of the Structure of the Vitreous and the Zonular Fibres. Biochemical Society Transactions, July 1991. PMID: 1794575 7.

Swasdison S, Mayne PM, Wright DW, Accavitti MA, Fitch JM, Linsenmayer TF, Mayne R: Monoclonal Antibodies that Distinguish Avian Type I and Type III Collagens: Isolation, Characterization and Immunolocalization in Various Tissue. Matrix 1992; 1: 56 - 65. PMID: 1560790 8.

Wright DW, McDaniels CN, Swasdison S, Accavitti MA, Mayne PM, Mayne R: Immunization with Undenatured Bovine Zonular Fibrils Results in Monoclonal Antibodies to Fibrillin. Matrix Biology 1994; 14: 41 - 49. PMID: 8061919 9.

Fulop ZL, Wright DW, Stein DG: The Pharmacology of Traumatic Brain Injury: Experimental Models and Clinical Trials. Neurology Reports 1998; 3:100-109. 10.

Wright DW, Bauer ME, Hoffman SW, Stein DG: Serum Progesterone Levels Correlate with Decreased Cerebral Edema after Traumatic Brain Injury in Male Rats. Journal of Neurotrauma 2001; 18:901-909. PMID: 11565602 11.

Chesnut RM, Carney NA, Adelson PD, Bratton SL, de Coudray, HEM, Goldstein B, Kochanek PM, Miller HC, Partington MD, Seldon, NR, Warden CR, Wright DW: Guidelines for the Acute Medical Management of Severe Traumatic Brain Injury in Infants, Children, and Adolescents, Pediatric Critical Care Medicine, 2003 Vol. 4, No. 3, (Suppl) and Critical Care Medicine, 2003 Vol. 31, No. 6. S481-S420 Suppl. PMID: 12847355 - 12847337 12.

Patel MM, Wright DW, Ratcliff JJ, Miller AM: Shedding New Light on the “Safe” Club Drug: Methylenedioxmethamphetamine (Ecstasy)-Related Fatalities. Academic Emergency Medicine. 2004 Vol. 11/2 pp 208-210. PMID: 14759969 13.

Wright DW, Ratcliff JJ, Lowery DW, Wald MW: Proxy Identification, A Time Dependent Analysis. Academic Emergency Medicine, 2004 Vol. 11/2 pp 204-207. PMID: 14759968 14.

Patel MM, Belson MG, Wright D, Lu H, Heninger M, Miller AM: Methylenedioxymethamphetamine (Ecstasy)-Related Myocardial Hypertrophy: An Autopsy Study: Resuscitation 2005 Aug;66(2):197-202. PMID: 15963623 15.

Pettus EH, Wright DW, Stein DG, Hoffman SW: Progesterone Treatment Inhibits the Inflammatory Agents that Accompany Traumatic Brain Injury. Brain Research, July 2005 5;1049(1):112-9. PMID: 15932748 16.

Wright DW, Ritchie JC, Mullins RE, Kellermann AL, Denson DD: Steady State Serum Concentration of Progesterone Following Intravenous Infusion in Patients with Acute Moderate to Severe Traumatic Brain Injury. The Journal of Clinical Pharmacology 2005 June, 45:6 pp640-648. PMID: 15901745

Barker JM, Ratcliff JJ, Goldstein FC, Ockerman J, Wright DW, LaPlaca MC. Portable, reduced-length neuropsychological testing for mild traumatic brain injury via a novel immersive environment: A usability study. Journal of Medical Engineering & Technology 31(3):161–9, 2007. PMID: 17454403 18.

Wright DW, Kellermann AL, Hertzberg VS, Clark PL, Frankel M, Goldstein FC, Salomone JP, Dent L, Harris OA, Ander, DS, Lowery DW, Patel M, Denson DD, Wald MM, Gupta S, Hoffman S, Stein DG: ProTECT™: a randomized clinical trial of progesterone for acute traumatic brain injury. Ann Emerg Med. 2007 Apr;49(4):391-402, 402.e1-2. Epub 2006 Sep 29. PMID: 17011666 19.

Bratton SL, Bullock MR, Carney N, Chesnut RM, Coplin W, Ghahar J, Clifton GL, McConnell Hammond FF, Harris OA, Hartl R, Maas AIR, Manley GT, Marion DW Narayan RK, Nemecek A, Newell DW, Pitts LH, Rosenthal G, Rosner MJ, Schouten J, Servadei F, Shutter LA, Stocchetti N, Timmons SD, Ullman JS, Videtta W, Walters BC, Willberger JE, Wright DW: Guidelines for the Acute Medical Management of Severe Traumatic Brain Injury, Journal of Neurotrauma, May 2007, Vol. 24, No. s1 : S-77 -S-82 PMID: 17511554-17511539 20.

Ratcliff JJ, Greenspan A, Goldstein FC, Wright DW, Stringer A, Bushnik T, Hammond F, Novack T, Whyte J: Gender and Traumatic Brain Injury: Do the Sexes Fare Differently. Brain Injury. Brain Inj. 2007 Sep;21(10):1023-30. PMID: 17891564 21.

Wright DW, Clark PL, Pentz R, Hertzberg V, Kellermann AL: Enrolling subjects by exception from consent versus proxy consent in trauma care research. Ann Emerg Med. 2008 Apr;51(4):355-60, 360.e1-3. Epub 2007 Oct 15. PMID: 17933428 22.

Wright DW, Hoffman SW, Virmani, S, Stein DG: Effects of medroxyprogesterone acetate on cerebral oedema and spatial learning performance after traumatic brain injury in rats. Brain Inj. 2008 Feb;22(2):107-13. PMID: 18240039 23.

Saatman KE, Duhaime AC, Bullock R, Maas AIR, Valadka A, Manley GT, [Wright D]: and Workshop Scientific Team And Advisory Panel Members: Classification of Traumatic Brain Injury for Targeted Therapies. J Neurotrauma. 2008 Jul;25(7):719-38. PMID: 18627252 24.

Badjatia N, Carney N, Crocco TJ, Fallat ME, Hennes HM, Jagoda AS, Jernigan S, Letarte PB, Lerner EB, Moriarty TM, Pons PT, Sasser S, Scalea T, Schleien CL, Wright DW; Brain Trauma Foundation; BTF Center for Guidelines Management. Guidelines for prehospital management of traumatic brain injury 2nd edition. Prehosp Emerg Care. 2008;12 Suppl 1:S1-52. No abstract available. PMID: 18203044 25.

Jagoda AS, Bazarian JJ, Bruns JJ Jr, Cantrill SV, Gean AD, Howard PK, Ghajar J, Riggio S, Wright DW, Wears RL, Bakshy A, Burgess P, Wald MM. American College of Emergency Physicians and Centers for Disease Control and Prevention. Clinical policy: neuroimaging and decision making in adult mild traumatic brain injury in the acute setting. Ann Emerg Med. 2008;52:714-748. PMID: 19027497 [also published in: J Emerg Nurs. 2009 Apr;35(2):e5-40. Review. PMID: 19285163 26.

Pentz R, Kellermann AL, Wright DW: Conducting Research on Issues Regarding Human Subjects Research Regulatory Compliance: A Responsibility of All Clinical Researchers. Ann Emerg Med. Volume 52, Issue 5, November 2008, Pages 574-575. PMID: 18970990 27.

Margulies S, Hicks R; [Wright, D]: Combination Therapies for Traumatic Brain Injury Workshop Leaders. Combination therapies for traumatic brain injury: prospective considerations. J Neurotrauma. 2009 Jun;26(6):925-39.PMID: 19331514 28.

Novelo SM, de Mouzinho AO, Macleod J, Sasser S, Wright D, Click L: Triad of alcohol, car accident, and trauma in drivers in the city and Province of Maputo. Revista Medica de Mocambique 2009: 10: 37-42. 29.

Wright DW, Brumfield JR, LaPlaca M, Goldstein FC, Kilgo P, Ravichandran T, Danielson ML: Use Of A Novel Technology To Detect Mild Cognitive Impairment In Elderly Patients, Blackwell Publishing Ltd., Int J Clin Pract 64(9):1190-7, Aug 2010 PMID: 20497262 30.

de Sousa Petersburgo, D, Keyes EC, Wright DW, Click LA, Macleod JBA, Sasser SM: The Epidemiology of Childhood Injury in Maputo, Mozambique, Int J Emerg Med. 2010 Jul 30;3(3):157-63. PMID: 21031039 31.

Menon DK, Scwab K, Wright DW, Mass AIR: Definition of Traumatic Brain Injury, Arch Phys Med Rehabil Vol 91, pp 1637-40, November 2010 PMID: 21044706 32.

Maas AIR, Harrison-Felix CL, Menon D, Adelson PD., Balkin T, Bullock R, Engel DC, Gordon W, Langlois J, Lew HL, Robertson C, Temkin N, Valadka A, Verfaellie M, Wainwright M, Wright DW, Schwab K: Common Data Elements for Traumatic Brain Injury: Recommendations from the interagency working group on demographics and clinical assessment, Arch Phys Med Rehabil Vol 91, pp 1641-49, November 2010 PMID: 21044707 33.

Cairns CB, Maier RV, Adeoye O, Baptiste D, Barsan WG, Blackbourne L, Burd R, Carpenter C, Chang D, Cioffi W, Cornwell E, Dean JM, Dyer C, Jaffe D, Manley G, Meurer WJ, Neumar R, Silbergleit R, Stevens M, Wang M, Weiner D, Wright D; NIH Roundtable on Emergency Trauma Research. Roundtable External Participants and Roundtable Steering Committee and Federal Participants. Ann Emerg Med. 2010 Nov;56(5):538-50. PMID: 21036294 34.

Maas AIR, Harrison-Felix CL, Menon D, Adelson PD, Balkin T, Bullock R, Engel DC, Gordon W, Langlois J, Lew HL, Robertson C, Temkin N, Valadka A, Verfaellie M, Wainwright M, Wright DW, Schwab K: Standardizing Data Collection in Traumatic Brain Injury, J Neurotrauma. 2011 Feb;28(2):177-87. Epub 2011 Feb 5. PMID: 21162610 35.

Bruce BB, Lamirel C, Wright DW, Ward A, Heilpern KL, Biousse V, Newman NJ: Non-mydriatic ocular fundus photography in the ED: the FOTO-ED study N Engl J Med. 2011 Jan 27;364(4):387-9 PMID: 21268749 36.

Jethá EA, Lynch CA, Houry DE, Rodrigues MA, Chilundo B, Sasser SM, Wright DW: Characteristic of victims of family violence seeking care at health centers in Maputo, Mozambique. J Emerg Trauma Shock. 2011 Jul;4(3):369-73. PMID: 21887028 37.

Jetha EAR, Lynch CA, Houry D, Rodrigues MA, Keyes CE, Chilundo B, Wright DW, Sasser SM: Treatment, Services and Follow-up for Victims of Family Violence in Health Clinics in Maputo, Mozambique, West J Emerg Med. 2011 Jul;12(3):348-53. PMID: 2173179 38.

Lynch CA, Houry DE, Dai D, Wright DW: Evidence-based Community Consultation for Traumatic Brain Injury. Acad Emerg Med. 2011 Aug 19. doi: 10.1111/j.1553-2712.2011.01153.x. PMID: 21854486 39.

Gaddis GM, Olsen JE, Wright DW: Pharmaceutical advertising policy of Academic Emergency Medicine was incompletely reported and mischaracterized in the statement of EMA’s new no-pharmaceutical ads policy. Emergency Medicine Australasia, doi: 10.1111/j.1742-6723.2011.01481.x 2011 Oct;23(5):654-5 PMID: 21995484 40.

Bruce BB, Lamirel C, Wright DW, Ward A, Heilpern KL, Biousse V, Newman NJ: Feasibility of Non-Mydriatic Ocular Fundus Photography in the Emergency Department: Phase I of the FOTO-ED Study. Acad Emerg Med. 2011 Sep;18(9):928-33. doi: 10.1111/j.1553-2712.2011.01147.x. PMID: 21906202 41.

Wright DW, Goldstein FC, Kilgo P, Howlett-Smith H, Robinson A, Fowler S, LaPlaca M: DETECT: A Novel Technology to Screen for Mild Cognitive Impairment in the primary care setting, Am J Alzheimers Dis Other Demen, 2011 Sep;26(6):484-91. Epub 2011 Nov 22. PMID: 22110158 42.

Lamirel C, Bruce BB, Wright DW, Delaney KP, Newman NJ, Biousse V: Quality of non-mydriatic digital fundus photography obtained by nurse practitioners in the emergency department: the FOTO-ED study: Ophthalmology. 2012 Mar;119(3):617-24. PMID: 22218140 43.

Bruce BB, Lamirel C, Wright DW, Biousse V, Newman NJ: Blood pressure threshold for abnormal ocular fundus findings is lower than expected. Hypertension. Feb 2012;59:e8-9. PMID: 22203745 44.

Lamirel C, Bruce BB, Wright DW, Newman NJ, Biousse V: Quality of non-mydriatic digital ocular fundus photography on the iPhone 3G: the FOTO-ED study. Arch Ophthalmol. 2012 Jul 1;130(7):939-40. doi: 10.1001/archophthalmol.2011.2488. PMID: 22776940 45.

Henderson AD, Biousse V, Newman NJ, Lamirel C, Wright DW, Bruce BB: Grade III or IV hypertensive retinopathy in the setting of hypertensive urgency. West J Emerg Med. 2012 Dec;13(6):529-34. doi: 10.5811/westjem.2011.10.6755. PMID: 23359839 46.

Price M, Hertzberg V, Wright DW: Does the sliding dichotomy result in higher powered clinical trials for stroke and traumatic brain injury research? Clin Trials. 2012 Oct 1. PMID 23027647 47.

Thulasi P, Fraser CL, Biousse V, Wright DW, Newman J, Bruce BB: Non-mydriatic ocular fundus photography among headache patients presenting to an emergency department. Neurology 2013 Jan 29;80(5):432-7. doi: 10.1212/WNL.0b013e31827f0f20. Epub 2013 Jan 2. PMID: 23284060 48.

Bruce BB, Thulasi P, Fraser CL, Keadey MT, Ward A, Heilpern KL, Wright DW, Newman NJ, Biousse V: Diagnostic Accuracy and Use of Nonmydriatic Ocular Fundus Photography by Emergency Physicians: Phase II of the FOTO-ED Study Ann Emerg Med. 2013 Jul;62(1):28-33. PMID: 23433654 49.

Dickert NW, Mah VA, Baren JM, Biros MH, Govindarajan P, Pancioli A, Silbergleit R, Wright DW, Pentz RD: Enrollment in research under exception from informed consent: The Patients' Experiences in Emergency Research (PEER) study. Resuscitation. 2013 Apr 16. S0300-9572(13)00214-1. PMID: 23603291 50.

Dickert NW, Mah VA, Biros MH, Harney DM, Silbergleit R, Sugarman J, Veledar E, Weinfurt KP, Wright DW, Pentz RD: Consulting Communities When Patients Cannot Consent: A Multicenter Study of Community Consultation for Research in Emergency Settings. Crit Care Med. 2013 Oct 18. [Epub ahead of print] PubMed PMID: 24145834 51.

Ziai WC, Tuhrim S, Lane K, McBee N, Lees K, Dawson K, Butcher K, Vespa P, Wright DW, Keyl PM, Mendelow AD, Kase C, Wijman C, Lapointe M, John S, Thompson R, Thompson C, Mayo S, Reilly P, Janis S, Awad I, Hanley DF, for the CLEAR Trial Investigators: A multicenter, randomized, double-blinded, placebo controlled phase III study of Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR III), Int J Stroke. 2014 Jun;9(4):536-42. doi: 10.1111/ijs.12097. Epub 2013 Aug 28. PMID: 24033910 52.

Wright DW, Yeatts SD, Silbergleit R, Palesch YY, Hertberg VS, Frankel M, Goldstein FC, Caveney AF, Howlett-Smith H, Bengelink EM, Manley GT, Merck LH, Janis LS, Barsan W; NETT Investigators: Very Early Administration of Progesterone for Acute Traumatic Brain Injury. N Engl J Med. 2014 Dec 25;371(26):2457-66. doi: 10.1056/NEJMoa1404304. Epub 2014 Dec 10. PMID: 25493974 53.

Biros, M; Dickert, N; Wright, DW; Mah V, Harney D, Silbergleit R, Denninghoff K Pentz R: Balancing Ethical Goals in Challenging Individual Participant Scenarios Occurring in a Trial Conducted with Exception from Informed Consent. Acad Emerg Med. 2015 Mar;22(3):340-6. doi: 10.1111/acem.12602. Epub 2015 Feb 25. PMID: 25716051 54.

Wright DW, Espinoza TR, Merck LH, Ratcliff JJ, Backster A, Stein DG: Gender Differences in Neurological Emergencies Part II: A Consensus Summary and Research Agenda on Traumatic Brain Injury, Academic Emergency Medicine. Acad Emerg Med. 2014 Dec;21(12):1414-20. doi: 10.1111/acem.12532. Epub 2014 Nov 24. PMID: 25420582 55.

McGregor AJ, Barr H, Greenberg MR, Safdar B, Wildgoose P, Wright DW, Hollander JE: Gender-specific Regulatory Challenges to Product Approval: A Panel Discussion. Acad Emerg Med. 2014 Dec;21(12):1334-8. doi: 10.1111/acem.12531. Epub 2014 Dec 1. PMID: 25443664 56.

Madsen TE, Seigel TA, Mackenzie RS, Marcolini EG, Wira CR, Healy ME, Wright DW, Gentile NT: Gender differences in neurologic emergencies part I: a consensus summary and research agenda on cerebrovascular disease. Acad Emerg Med. 2014 Dec;21(12):1403-13. doi: 10.1111/acem.12528. Epub 2014 Nov 24. PMID: 25422086 57.

Vuong LN, Thulasi P, Biousse V, Garza P, Wright DW, Newman NJ, Bruce BB. Ocular fundus photography of patients with focal neurologic deficits in an emergency department. NEUROLOGY 5/24/2015. pii: 10.1212/WNL.0000000000001759. PMID: 26109710 58.

Dickert NW, Scicluna VM, Baren JM, Biros MH, Fleischman RJ, Govindarajan PR, Jones EB, Pancioli AM, Wright DW, Pentz RD: Patients' perspectives of enrollment in research without consent: the patients' experiences in emergency research-progesterone for the treatment of traumatic brain injury study. Crit Care Med. 2015 Mar;43(3):603-12. doi: 10.1097/CCM.0000000000000747. PMID: 25574795 59.

Miller JB, Heitsch L, Siket MS, Schrock JW, Wira III CR, Lewandowski C, Madsen TE, Merck LH, Wright DW and From the SAEM Neurologic Emergencies Interest Group Writing Group: The Emergency Medicine Debate on tPA for Stroke: What Is Best for Our Patients? Efficacy in the First Three Hours Article first published online: 5/25/2015 DOI: 10.1111/acem.12712 60.

Dickert NW, Brown J, Cairns CB, Eaves-Leanos A, Goldkind SF, Kim SY, Nichol G, O'Conor KJ, Scott JD, Sinert R, Wendler D, Wright DW, Silbergleit R: Confronting Ethical and Regulatory Challenges of Emergency Care Research With Conscious Patients. Ann Emerg Med. 2015 Dec 18. pii: S0196-0644(15)01425-0. doi: 10.1016/j.annemergmed.2015.10.026. [Epub ahead of print] PMID: 26707358 61.

Goldstein FC, Caveney AF Hertzberg VS, Silbergleit R, Yeatts SD, Palesch YY, Levin HS, Wright DW, for the NETT Investigators: Very Early Administration of Progesterone Does Not Improve Neuropsychological Outcomes in Subjects with Moderate to Severe TBI. Journal of Neurotrauma. 10.1089/neu.2015.4313. 3/3/2016 PMID: 26973025 62.

Ghajar J, Carney N, Totten AM, O'Reilly C, Ullman JS, Hawryluk GWA, Bell MJ, Bratton SL, Chesnut R, Harris OA, Kissoon N, Rubiano AM, Shutter L, Tasker RC, Vavilala MS, Wilberger J, Wright DW. “Guidelines for the Management of Severe Traumatic Brain Injury 4th Edition" Neurosurgery. 2016 Sep 20. PMID: 27654000 63.

Kosoris N, Liu BT, Phelps SE, Medda S, Swanson E, Gore RK, LaPlaca MC, Evans K, Hendershot K, Wright DW, Espinoza T: Virtually Transforming DETECT: Moving a 2-D Gamified Health Assessment to Virtual Reality. Proceeding I3D '16 Proceedings of the 20th ACM SIGGRAPH Symposium on Interactive 3D Graphics and Games Pages 207-208 ACM New York, NY, USA ©2016 ISBN: 978-1-4503-4043-4 doi>10.1145/2856400.2876009 ( 64.

Lumba-Brown A; Yeates KO; Gioia G; Turner M; Benzel E; Suskauer S; Giza C; Joseph M; Broomand C; Weissman B; Gordon W; Wright DW; Moser RS; McAvoy K; Ewing-Cobbs L; Duhaime A; Putukian M; Holshouser B; Paulk D; Wade S; Herring S; Halstead M; Keenan H; Choe M; Christian CW; Guskiewicz K; Raksin P; Gregory A; Mucha A; Taylor HG; Callahan J; DeWitt J; Collins M; Kirkwood M; Ragheb J; Ellenbogen R; Spinks TJ; Ganiats TG; Sabelhaus L; Altenhofen K; Schoessler S; O’Connor RE; Timmons S.: Report from the Pediatric Mild Traumatic Brain Injury Guideline Workgroup: Systematic Review and Clinical Recommendations for Healthcare Providers on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children. Report from the Pediatric Mild Traumatic Brain Injury Guideline Workgroup, CDC. August 24, 2016 65.

Hanley DF, Lane K, McBee N, Ziai W, Tuhrim S, Lees KR, Dawson J, Gandhi D, Ullman N, Mould A, Mayo SW, Mendelow AD, Gregson B, Butcher K, Vespa P, Wright DW, Kase CS, Carhuapoma JR, Keyl PM, Diener-West M, Muschelli J, Betz JF, Thompson CB, Sugar EA, Yenokyan G, Janis S, John S, Harnof S, Lopez GA, Aldrich EF, Harrigan MR, Ansari S, Jallo J, Caron JL, LeDoux D, Adeoye O, Zuccarello M, Adams HP, Rosenblum M, Thompson RE, Awad IA, for the CLEAR III Investigators. Thrombolytic removal of intraventricular haemorrhage in treating severe stroke: Results of the CLEAR III trial, The Lancet. 2017 Feb 11;389(10069):603-611. doi: 10.1016/S0140-6736(16)32410-2. PMID: 28081952 66.

Hanley D, Prichep L, Bazarian J, Huff J, Naunheim R, Garrett J, Jones E, Wright DW, O'Neill J, Badjatia N, Gandhi D, Curley K, Chiacchierini R, O'Neil B, Hack D: Emergency Department triage of traumatic head injury using brain electrical activity biomarkers: a multisite prospective observational validation trial. Academic Emergency Medicine. Acad Emerg Med. 2017 Feb 8. doi: 10.1111/acem.13175. PMID: 28177169 67.

Miller JB, Merck LH, Wira CR, Meurer WJ, Schrock JW, Nomura JT, Siket MS, Madsen TE, Wright DW, Panagos PD, Lewandowski C.: The Advanced Reperfusion Era: Implications for Emergency Systems of Ischemic Stroke Care. Ann Emerg Med. 2017 Feb;69(2):192-201. doi: 10.1016/j.annemergmed.2016.06.042. PMID: 27600649 68.

Keshavamurthy KN, Leary OP, Merck LH Kimia B, Collins S, Wright DW, Allen JW, Brock JF: "Machine learning algorithm for automatic detection of CT-identifiable hyperdense lesions associated with traumatic brain injury", Proc. SPIE 10134, Medical Imaging 2017: Computer-Aided Diagnosis, 101342G (March 23, 2017); doi:10.1117/12.2254227; https://dx.doi.org/10.1117/12.2254227 69.

Scicluna VM, Ali MK, Pentz RD, Wright, DW, Dickert NW: Does Experience Matter? Implications for Community Consultation for Research in Emergency Settings. American Journal of Bioethics - AJOB Empirical Bioethics https://dx.doi.org/10.1080/23294515.2017.1308978, 3/24/2017 70.

Whitesides LW, Baren JM, Biros MH, Fleischman RJ, Govindarajan PR, Jones EB, Pancioli AM, Pentz RD, Scicluna VM, Wright DW, Dickert NW: Impact of individual clinical outcomes on trial participants' perspectives on enrollment in emergency research without consent. Clin Trials. 2017 Apr;14(2):180-186. doi: 10.1177/1740774516677276. Epub 2016 Nov 15. 71.

Denninghoff KR, Nuño T, Pauls Q, Yeatts SD, Silbergleit R, Palesch YY, Merck LH, Manley GT, Wright DW. Prehospital Intubation is Associated with Favorable Outcomes and Lower Mortality in ProTECT III. Prehosp Emerg Care. 2017 May 10:1-6. doi: 10.1080/10903127.2017.1315201. PMID: 28489506 72.

Hanley D, Prichep LS, Badjatia N, Bazarian J, Chiacchierini R, Curley KC, Garrett J, Jones E, Naunheim R, O'Neil B, O'Neill J, Wright DW, Huff JS. A Brain Electrical Activity (EEG)-Based Biomarker of Functional Impairment in Traumatic Brain Injury: A Multi-Site Validation Trial. J Neurotrauma. 2017 Sep 21. doi: 10.1089/neu.2017.5004. PMID: 2859960 73.

Curley KC, O’Neil BJ, Naunheim R, Wright, DW. Intracranial Pathology (CT+) in Emergency Department Patients With High GCS and High Standard Assessment of Concussion (SAC) Scores Journal of Head Trauma Rehabilitation. DOI:10.1097/HTR.0000000000000355 11/2017 74.

Sachdeva V, Vasseneix C, Hage R, Bidot S, Clough LC, Wright DW, Newman NJ, Biousse V, Bruce BB: Optic nerve head edema among patients presenting to the emergency department. Neurology. DOI: 10.1212/WNL.0000000000004895 1/5/2018 PMID: 29305439 75.

Salhi BA, White MH, Pitts SR, Wright DW: Homelessness and Emergency Medicine: A Review of the Literature. Acad Emerg Med. DOI: 10.1111/acem.13358, 12/9/17 PMID: 29223132 76.

Bruce BB, Bidot S, Hage R, Fajoles-Vasseneix C, Melomed M, Keadey MT, Wright DW, Newman NJ, Biousse V. Fundus photography vs. Ophthalmoscopy Outcomes in the Emergency Department (FOTO-ED) Phase III: Web-based, in-service training of emergency providers. Neuro-Ophthalmology. DOI: 10.1080/01658107.2017.1419368 1/24/2018 PMID: 30258471 77.

Gimbel RW, Pirrallo RG, Lowe SC, Wright DW, Zhang L, Woo MJ, Fontelo P, Liu F, Connor Z: Effect of clinical decision rules, patient cost and malpractice information on clinician brain CT image ordering: a randomized controlled trial. BMC Medical Informatics and Decision Making (2018) 18:20 https://doi.org/10.1186/s12911-018-0602-1 78.

Kenzie ES, Parks EL, Bigler ED, Wright DW, Lim MM, Chesnutt JC, Hawryluk GWJ, Gordon W, Wakeland W. The Dynamics of Concussion: Mapping Pathophysiology, Persistence, and Recovery With Causal-Loop Diagramming. Front Neurol. 2018 Apr 4;9:203. doi: 10.3389/fneur.2018.00203. eCollection 2018. PMID: 29670568 79.

Pinto L, Lein A, Mahoque R, Wright DW, Sasser SM, Staton CA.; A cross-sectional exploratory study of knowledge, attitudes, and practices of emergency health care providers in the assessment of child maltreatment in Maputo, Mozambique. BMC Emerg Med. 2018 May 9;18(1):11. doi: 10.1186/s12873-018-0162-9. PMID: 29743037 80.

Puskarich MA, Callaway C, Silbergleit R, Pines JM, Obermeyer Z, Wright DW, Hsia RY, Shah MN, Monte AA, Limkakeng AT Jr, Meisel ZF, Levy PD: Priorities to Overcome Barriers Impacting Data Science Application in Emergency Care Research. Acad Emerg Med. 2018 Jul 18. doi: 10.1111/acem.13520. PMID: 30019795 81.

Lumba-Brown A, Yeates KO, Sarmiento K, Breiding MJ, Haegerich TM, Gioia GA, Turner M, Benzel EC, Suskauer SJ, Giza CC, Joseph M, Broomand C, Weissman B, Gordon W, Wright DW, Moser RS, McAvoy K, Ewing-Cobbs L, Duhaime AC, Putukian M, Holshouser B, Paulk D, Wade SL, Herring SA, Halstead M, Keenan HT, Choe M, Christian CW, Guskiewicz K, Raksin PB, Gregory A, Mucha A, Taylor HG, Callahan JM, DeWitt J, Collins MW, Kirkwood MW, Ragheb J, Ellenbogen RG, Spinks TJ, Ganiats TG, Sabelhaus LJ, Altenhofen K, Hoffman R, Getchius T, Gronseth G, Donnell Z, O'Connor RE, Timmons SD. Diagnosis and Management of Mild Traumatic Brain Injury in Children: A Systematic Review. JAMA Pediatr. 2018 Sep 4:e182847. doi: 10.1001/jamapediatrics.2018.2847. [Epub ahead of print] PMID: 30193325 82.

Lumba-Brown A, Yeates KO, Sarmiento K, Breiding MJ, Haegerich TM, Gioia GA, Turner M, Benzel EC, Suskauer SJ, Giza CC, Joseph M, Broomand C, Weissman B, Gordon W, Wright DW, Moser RS, McAvoy K, Ewing-Cobbs L, Duhaime AC, Putukian M, Holshouser B, Paulk D, Wade SL, Herring SA, Halstead M, Keenan HT, Choe M, Christian CW, Guskiewicz K, Raksin PB, Gregory A, Mucha A, Taylor HG, Callahan JM, DeWitt J, Collins MW, Kirkwood MW, Ragheb J, Ellenbogen RG, Spinks TJ, Ganiats TG, Sabelhaus LJ, Altenhofen K, Hoffman R, Getchius T, Gronseth G, Donnell Z, O'Connor RE, Timmons SD. Centers for Disease Control and Prevention Guideline on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children. JAMA Pediatr. 2018 Sep 4:e182853. doi: 10.1001/jamapediatrics.2018.2853. [Epub ahead of print] PMID: 30193284 83.

Lumba-Brown A, Wright DW, Sarmiento K, Houry D., Emergency Department Implementation of the Centers for Disease Control and Prevention Pediatric Mild Traumatic Brain Injury Guideline Recommendations. Ann Emerg Med. 2018 May 10. pii: S0196-0644(18)30321-4. doi: 10.1016/j.annemergmed.2018.03.045. [Epub ahead of print] No abstract available. PMID: 29753521 84.

Merck LH, Yeatts, Sharon D, Silbergleit R, Manley GT, Pauls Q, Palesch Y, Conwit R, Le Roux P, Miller J, Franke M, Wright DW: The Effect of Goal-Directed Therapy on Patient Morbidity and Mortality After Traumatic Brain Injury, Results From the Progesterone for the Treatment of Traumatic Brain Injury III Clinical Trial. Critical Care Medicine: February 5, 2019 - Volume Online First - Issue – p doi: 10.1097/CCM.0000000000003680 85.

Hager DN, Hooper MH, Bernard GR, Busse LW, Ely EW, Fowler AB, Gaieski DF, Hall A, Hinson JS, Jackson JC, Kelen GD, Levine M, Lindsell CJ, Malone RE, McGlothlin A, Rothman RE, Viele K, Wright DW, Sevransky JE, Martin GS. The Vitamin C, Thiamine, and Steroids in patients with Sepsis (VICTAS) Protocol: A prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial. TRIALS 2019 (In Press) 86.

Frankel M, Fan L, Yeatts SD, Jeromin A, Vos PE, Wagner AK M.D, Wolf BJ, Pauls Q, Lunney M, Merck LH10, Hall CL11, Palesch Y, Silbergleit R, Wright DW: The Association of Very Early Serum levels of S100B, GFAP, UCH-L1, and SBDP with Outcome in ProTECT III. J Neurotrauma. 2019 Feb 22. doi: 10.1089/neu.2018.5809. [Epub ahead of print]