Doctor's Bio
Dr. Andre L. Holder is a clinician scientist with multiple specialty backgrounds (emergency medicine, internal medicine, and critical care medicine). He is an assistant professor in the Division of Pulmonary, Allergy, Critical Care and Sleep Medicine at Emory University. Through collaborations with colleagues in the Department of Biomedical Informatics, his primary area of research focus is the successful clinical deployment of advanced data-driven (machine learning) algorithms to predict clinical decompensation. His research goals are to (1) determine appropriate timing and use of interventions to prevent or mitigate syndromes of critical illness (e.g. sepsis) by forecasting the evolution of patient decompensation and organ failure; (2) advance the understanding of sepsis pathophysiology through innovative data science techniques; and (3) identify novel dynamic physiologic biomarkers in sepsis. Other areas of research interest include early sepsis resuscitation, cardiopulmonary resuscitation, and hemodynamic monitoring. He attends in the medical ICU at Grady Memorial Hospital and a mixed medical/surgical ICU at Emory Midtown Hospital.
Board Certifications
American Board of Internal Medicine
Affiliations
Emory
Education & Training
- Medical School: SUNY Downstate Medical Center
- Residency: SUNY Downstate Medical Center
Fellowships
University of Pittsburgh School of Medicine
Locations and Directions
Grady Memorial Hospital
Phone: (404) 616-1000
Location:
80 Jesse Hill Jr Drive SE
Atlanta, GA 30303
Publications
- Can we predict the future of respiratory failure prediction?
Pearce AK, Nemati S, Goligher EC, Hough CL, Holder AL, Wardi G, Yang P, Boussina A, Lyons PG, Sahetya S, Malhotra A, Rogers A
Critical care (London, England). 2025;29(1):253.
PMID: 40537867 - Mitigating Bias in Machine Learning Models with Ethics-Based Initiatives: The Case of Sepsis.
D Banja J, Xie Y, R Smith J, Rana S, L Holder A
The American journal of bioethics : AJOB. 2025;
PMID: 40354171 - Improving clinical decision support through interpretable machine learning and error handling in electronic health records.
Arora M, Mortagy H, Dwarshuis N, Wang J, Yang P, Holder AL, Gupta S, Kamaleswaran R
Journal of the American Medical Informatics Association : JAMIA. 2025;
PMID: 40261883 - Should AI models be explainable to clinicians?
Abgrall G, Holder AL, Chelly Dagdia Z, Zeitouni K, Monnet X
Critical care (London, England). 2024;28(1):301.
PMID: 39267172 - Moderate IV Fluid Resuscitation Is Associated With Decreased Sepsis Mortality.
Corl KA, Levy MM, Holder AL, Douglas IS, Linde-Zwirble WT, Alam A
Critical care medicine. 2024;52(11):e557-e567.
PMID: 39177437 - Racial Differences in Accuracy of Predictive Models for High-Flow Nasal Cannula Failure in COVID-19.
Yang P, Gregory IA, Robichaux C, Holder AL, Martin GS, Esper AM, Kamaleswaran R, Gichoya JW, Bhavani SV
Critical care explorations. 2024;6(3):e1059.
PMID: 38975567 - A Delphi Process to Identify Relevant Outcomes That May Be Associated With a Predictive Analytic Tool to Detect Hemodynamic Deterioration in the Intensive Care Unit.
Holder AL, Khanna AK, Scott MJ, Rossetti SC, Rinehart JB, Linn DD, Weichert J, Dellinger RP
Cureus. 2023;15(12):e50169.
PMID: 38186415 - Facilitating the Next Paradigm Shift in Critical Care Through Artificial Intelligence.
Holder AL, Kamaleswaran R
Critical care clinics. 2023;39(4):xiii-xiv.
PMID: 37704342 - HIRA: Heart Rate Interval based Rapid Alert score to characterize autonomic dysfunction among patients with sepsis-related acute respiratory failure (ARF).
Krishnan P, Rad MG, Agarwal P, Marshall C, Yang P, Bhavani SV, Holder AL, Esper A, Kamaleswaran R
Physiological measurement. 2023;
PMID: 37652033 - Serial Measurements of Protein Biomarkers in Sepsis-Induced Acute Respiratory Distress Syndrome.
Yang P, Iffrig E, Harris F, Holder AL, Martin GS, Esper AM
Critical care explorations. 2022;4(10):e0780.
PMID: 36284549
PLANNING
PREPARING FOR YOUR VISIT
Whether you’re a patient or you’re visiting one, a little planning beforehand can make your visit to Grady easier and more comfortable. Here, you’ll find everything you need to prepare for your visit, including an appointment checklist, admissions information, dining options, and much more.